Background: In acne, several studies report a poor adherence to treatments. We evaluate, in a real-life setting conditions,\nthe impact of compliance to physicianââ?¬â?¢s instructions, recommendations and adherence to the treatments on clinical\noutcome in patients with mild to moderate acne in an observational, non-interventional prospective study carried out in\n72 Dermatologic Services in Spain (ACTUO Trial).\nMethods: Six-hundred-forty-three subjects were enrolled and 566 patients (88 %) completed the 3 study visits. Study\naimed to evaluate the impact of adherence (assessed with ECOB scale) on clinical outcome, as well as how the use of\nspecific adjuvant treatments (facial cleansing, emollient, moisturizing and lenitive specific topical products) influences\ntreatmentââ?¬â?¢s adherence and acne severity (0ââ?¬â??5 points score). Recommendation of specific adjuvant skin barrier repair\nproducts was made in 85.2 %.\nResults: Overall, clinical improvement was observed throughout follow-up visits with an increased proportion of patients\nwho reported reductions of ââ?°Â¥50 % on the total number of lesions (2 months: 25.2 %; 3 months: 57.6 %) and reductions\nof severity scores (2.5, 2.0 and 1.3 at 1, 2 and 3 months after treatment, respectively). Adherence to treatment was\nassociated with a significant reduction on severity grading, a lower number of lesions and a higher proportion of patients\nwith ââ?°Â¥50 % improvement.\nConclusions: Good adherence to medication plus adherence to adjuvants was significantly associated with a higher\nclinical improvement unlike those that despite adherence with medication had a low adherence to adjuvants. A good\nadherence to adjuvant treatment was\nassociated with improved adherence and better treatment outcomes in mild to moderate acne patients.\n(ISRCTN Registry: ISRCTN14257026).
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